49ers vs. Eagles predictions: Who will win? Experts' picks

The San Francisco 49ers are just a few hours away from their NFC wild card game against the Philadelphia Eagles at Lincoln Financial Field.

They've battled an influx of injuries throughout the season, including several key losses. However, the 49ers didn't let that limit them. San Francisco went 12-5 in the 2025 regular season, winning six of their last seven games.

The 49ers look to keep their momentum as they travel to Philadelphia to face the defending Super Bowl champion Eagles, led by Jalen Hurts and Saquon Barkley. Philadelphia aims to get back to the championship game and repeat as top dog – or bird – in the NFL.

USA TODAY Sports experts, along with analysts from other publications and networks, have provided their predictions for who will win between the 49ers and Eagles. Here's what they had to say:

Experts pick 49ers vs. Eagles

Here are expert picks for 49ers vs. Eagles in their wild-card showdown:

USA TODAY Sports

• Jarrett Bell: Eagles
• Nick Brinkerhoff: Eagles
• Chris Bumbaca: Eagles
• Nate Davis: Eagles
• Tyler Dragon: Eagles
• Mike Middlehurst-Schwartz: Eagles

Sports Illustrated

• Clare Brennan: Eagles
• Mitch Goldich: Eagles
• Gilberto Manzano: Eagles
• Conor Orr: Eagles
• John Pluym: 49ers
• Matt Verderame: 49ers

Bleacher Report

• Gary Davenport: 49ers
• Kris Knox: 49ers
• Moe Moton: 49ers
• Wes O'Donnell: 49ers
• Brent Sobleski: 49ers
• Brad Gagnon: Eagles
• Ian Hanford: Eagles

NFL.com

• Ali Bhanpuri: Eagles
• Tom Blair: Eagles
• Brooke Cersosimo: Eagles
• Gennaro Filice: Eagles
• Dan Parr: Eagles

CBS Sports

• Pete Prisco: Eagles
• Jared Dubin: 49ers
• Ryan Wilson: 49ers
• John Breech: 49ers
• Tyler Sullivan: Eagles
• Dave Richard: Eagles
• Jamey Eisenberg: Eagles

ESPN

• Matt Bowen: Eagles
• Mike Clay: Eagles
• Jeremy Fowler: Eagles
• Dan Graziano: 49ers
• Kaitlyn Kahler: Eagles
• Pamela Maldonado: 49ers
• Eric Moody: 49ers
• Jason Reid: Eagles
• Lindsey Thiry: Eagles

49ers vs. Eagles odds

NFL odds courtesy of BetMGM, as of Saturday evening.

• Spread: Philadelphia (-6)
• Moneyline: Philadelphia (-275); San Francisco (+225)
• Total: O/U 44.5 points