Toronto Blue Jays at Milwaukee Brewers odds, picks and predictions

The Toronto Blue Jays (7-9) and the Milwaukee Brewers (8-8) play the middle contest of a 3-game interleague series Wednesday at American Family Field in Milwaukee, Wisconsin. First pitch is scheduled for 7:40 p.m. ET. Let's analyze MLB odds around the Blue Jays vs. Brewers odds and make our expert MLB picks and predictions for the best bets.

Season series: Blue Jays lead 1-0

Toronto picked up a wild 9-7 road win in 10 innings in the series opener Tuesday as slight underdogs (+102) as the Over (7) cashed. SS Andres Gimenez and CF Daulton Varsho socked solo homers in the victory, while 1B Vladimir Guerrero Jr. doubled in the go-ahead run in the 10th. Milwaukee has dropped 6 in a row, its longest losing streak since 2023. 1B Jake Bauers had a 3-run HR in the losing effort.

Toronto has won 3 of the past 5 games, while the Over has cashed in 4 in a row. The road win in the series opener was the first of the season after going 0-3 in the first 3 on the road April 3-5 at Chicago White Sox.

Milwaukee has lost 4 in a row at home, despite 13 total runs scored in the past 2 games. The Brewers have allowed 5 or more runs in 7 of the past 9 outings since April 4, giving up an average of 6.0 runs per game (RPG) in the 9-game span. The Over is 3-1 in the past 4 outings, and 6-3 in that aforementioned 9-game run.

The Brewers placed LF Christian Yelich (groin) on the 10-day injured list Tuesday after he left Sunday's loss to Washington. He joins CF Jackson Chourio (hand) and 1B Andrew Vaughn (hand) on the shelf, as both are also on the IL.

Blue Jays at Brewers projected starters

RHP Dylan Cease vs. RHP Chad Patrick

Cease (0-0, 2.45 ERA) will make his fourth start of 2026. He has a 1.43 WHIP, 5.5 BB/9, 16.0 K/9 in 14 2/3 innings.

• Last start: No-decision, 5 IP, 2 R (1 ER), 4 H, 4 BB, 8 K in 4-3 home win vs. L.A. Dodgers last Wednesday
• 2026 on road: 1 start, No-decision, 4 1/3 IP, 3 R (2 ER), 5 H, 3 BB, 6 K in 5-4 loss in 10 innings vs. White Sox April 3
• Career vs. Brewers: 1-1, 3.18 ERA (22 2/3 IP, 8 ER), 19 H, 11 BB, 32 K, 1.32 WHIP, 12.7 K/9 in 4 starts

Patrick (1-0, 0.73 ERA) has made 2 starts and 1 relief appearance in 2026. He has a 1.38 WHIP, 3.7 BB/9 and 5.1 K/9 in 12 1/3 innings.

• Last start: Win, 5 IP, 0 ER, 4 H, 3 BB, 3 K in 5-2 road victory vs. Kansas City Royals April 4
• Last appearance: 3 IP, 0 ER, 3 H, 1 BB, 0 K in 7-3 home loss Friday vs. Washington Nationals in relief appearance
• 2026 at home (1 start, 2 appearances): 0-0, 1.23 ERA (7 1/3 IP, 1 ER), 1 HR, 2 BB, 4 K
• Has never faced Blue Jays

Blue Jays at Brewers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:54 a.m. ET.

• Moneyline (ML): Blue Jays -120 (bet $120 to $100) | Brewers +100 (bet $100 to win $100)
• Run line (RL)/Against the spread (ATS): Blue Jays -1.5 (+145) | Brewers +1.5 (-175)
• Over/Under (O/U): 7.5 (O: -105 | U: -115)

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Blue Jays at Brewers picks and predictions

Prediction

Blue Jays 3, Brewers 2

Moneyline

The BLUE JAYS (-120) are a solid play as slight road favorites as Toronto looks to clinch a series win, but expect a surprisingly decent pitching duel.

Proceed with caution, though, as Toronto's lone win in 4 road games came Tuesday night. But, Milwaukee is on a 6-game skid, and it cannot be trusted, either.

Run line/Against the spread

If you're ultra-conservative as a bettor, take the BREWERS +1.5 (-175) catching the run and a half at home. While Milwaukee has dropped 6 in a row, Patrick has been surprisingly effective in his 2 starts and 1 relief appearance, allowing just a single run in 46 at-bats.

As a favorite on the run line, Toronto is 1-6 in the past 7 tries.

Over/Under

UNDER 7.5 (-115) is a strong play, as we should get surprisingly decent pitching from Cease and Patrick.

Be careful, though, as the Over has cashed in 4 in a row for Toronto, and the total has gone high in 3 of the past 4 outings for Milwaukee. The Brewers have managed just 3.2 RPG in the past 6 outings, and they'll have difficulty plating runs against Cease.

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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